Researchers at the University of Zurich have found out, why not look promising stroke drug:
In animal experiments, they have shown that a transporter protein from the administered active ingredients of a group of drugs from the brain. If this protein is blocked in stroke therapy might be more successful in the future as to how the University communicates.
Cause of stroke is usually a sudden circulatory disorder of the brain. This occurs when a blood clot closes one of the vessels that supply blood to the brain. As a result, the nerve cells are deprived of oxygen and nutrients. They are thus often permanently damaged.
In the past 15 years, scientists have tried in vain to the information to protect the less vascularized nerve cells by drugs from the group of so-called neuroprotective agents.
The reason for the failed trials was unclear. The working group of neurologists Dirk Hermann of the University of Zurich has now demonstrated that the administered drugs transported in highly active in brain-damaged region back into the bloodstream to be.
Department of Neurology, the researchers have demonstrated in animal experiments that the transporter protein is formed Mdr-1 increased within hours of a stroke in less perfused brain tissue. Mdr-1 is able to convey the Medikamentein administered into the bloodstream, thereby preventing that these accumulate in the damaged brain tissue.
By the scientists, the transporter protein Mdr-1 inhibited, they were able to increase the concentration of different survival-promoting substances up to ten times, thus improving the effectiveness of the drug significantly.
Based on their observations, the researchers are convinced that Mdr-1 is responsible for numerous neuroprotective agents have failed in stroke therapy.
Their discovery opens up important new perspectives for stroke therapy, it said. Drugs that inhibit Mdr-1, are already in clinical development phase.
Should be possible through their commitment to inject drugs more efficiently than ever before in the brain and the rest of the less-vascularized tissue to ensure durable, the researchers hope.
Source: netdoktor.de
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