Used early on, by limiting the brain hemorrhage and could thus attenuate the degree of disability significantly.
This demonstrates an international study published in the journal "The New England Journal of Medicine" (NEJM 2005; 352, 777-785).
The genetically engineered drug used was "eptacog alfa" to the natural clotting protein Factor VIIa equivalent. The study was conducted with 399 patients from 20 countries. Was allowed to participate only stroke patients, whose cerebral hemorrhage by computed tomography (CT) clearly established.
It also authorized no more than three hours have elapsed since the onset of the stroke, so that the bleeding was still fresh. "Only then the treatment is a 'factor VIIa' drug-like at all useful," said Professor Martin Grond, a board member of the German Stroke Society (DSG).
The drug reduced the extent of cerebral hemorrhage significantly. Accordingly, the mortality rate decreased in the first 90 days of 29 percent to 19 percent. The proportion of patients who died or which were a severe disability fell significantly from 69 to 53 percent. , Seven patients with cerebral hemorrhage with factor VIIa treatment, can save a patient from death or serious disability.
But the treatment is associated with risks: The genetically engineered Factor VIIa can cause complications such as heart attacks or ischemic strokes, even - as a result of blood clotting in the arteries. This complication occurred in seven percent of patients who received factor VIIa, but only two percent in the placebo group.
In further studies will investigate whether the complication rate is lower. "Therefore, treatment should initially be used only with caution," calls for the DSG. One in six stroke is the result of a cerebral hemorrhage. Often they are people with a high pressure condition in which it spontaneously - that is, without external injury - a hemorrhage occurs into the brain. "There was no effective treatment so far," said Grond. To die today, two out of three patients suffering or serious disability.
Source: netdoktor.de
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